Peripheral opioids in inflammatory pain

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Peripheral opioids in inflammatory pain.

Topically applied opioids have provided effective analgesia without adverse effects, including tolerance, in adult patients with painful inflammatory conditions. The presumed mechanism of action is by interaction with opioid receptors which are sited on sensory nerve terminals and which may be up-regulated in inflammation. The use of peripherally acting opioids has not been studied in paediatri...

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The aim in using opioid drugs in chronic pain is optimal pain relief with a minimum of side effects. A rational approach requires understanding of the clinical pharmacology of opioids given by a variety of routes, for the differences between routes may be greater than the differences between drugs given by the same route. Those using opioids in chronic pain differentiate between their clinical ...

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Opioids for neuropathic pain.

BACKGROUND The use of opioids for neuropathic pain remains controversial. Studies have been small, have yielded equivocal results, and have not established the long-term risk-benefit ratio of this treatment. OBJECTIVES To assess the efficacy and safety of opioid agonists for the treatment of neuropathic pain. SEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (2n...

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Opioids and neuropathic pain.

Opioids are broad spectrum analgesics that may be beneficial to alleviate the intense perception of algesia in patients suffering with pain. They have been one of the most controversial analgesics, in part because of their potential for addiction. Opioids or any currently available analgesic will not provide effective analgesia for every patient with chronic neuropathic pain (NP), but overall o...

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The number of available opioid preparations, each with differing chemical properties, structure and opioid receptor affinity, increases with time. The efficacy of these opioids in the treatment of pain arising from a diverse range of disorders is beyond question. With the passage of time, the list of those conditions where an opioid is recommended as a treatment option increases, and that list ...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 2004

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.2003.032003